Antigenicity of Gelatin
نویسنده
چکیده
The effects of physical and enzymatic treatments of gelatin on the gelatin-antigelatin reaction have been presented. The data obtained indicate that the gelatin-antigelatin reaction is indeed a specific one. It appears that a definite limiting molecular size and specific molecular pattern of this molecular unit are necessary for reaction with antibody.
منابع مشابه
Studies on the chemical basis of the antigenicity of proteins. 2. Antigenic specificity of polytyrosyl gelatins.
In the preceding paper it was shown that the attachment of tyrosine, tryptophan or phenylalanine peptides to gelatin converts it into a relatively powerful antigen. The serological specificity of these gelatin derivatives varied according to the nature and the length of the peptides attached. Thus the specificity of polytyrosyl gelatin (10% of tyrosine residues) and polytryptophyl gelatin (25% ...
متن کاملIi. Antigenicity of Gelatin in Rabbits and Other Species
Normally occurring antibodies to gelatin have been demonstrated in sera from many species. Immunization of rabbits with gelatin has been successful when adjuvant techniques were employed.
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The non-antigenicity of gelatin was attributed for a long time to its lack of aromatic amino-acids. Later, Landsteiner [1919] and Hooker & Boyd [1932] introduced aromatic determinant groups into the gelatin molecule by coupling it with diazotized arsanilic acid. Injection of arsanil-azo-gelatin into rabbits furnished inmmune sera which gave slight precipitates with the arsanil-azo-compounds of ...
متن کاملI. Antigenicity of Oxypolygelatin and Gelatin in Man
It has been demonstrated that there are normally occurring antibodies to gelatin in human sera. Immunization with gelatin can in many cases increase the antibody level. The presence of these antibodies does not result in cutaneous reactions of the wheal and erythema type after injection of antigen. Many of the properties of the gelatin-antigelatin reaction and the precipitates formed are those ...
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BACKGROUND Development of an effective non-viral vaccine against hepatitis C virus infection is of a great importance. Gelatin nanoparticles (Gel.NPs) have an attention and promising approach as a viable carrier for delivery of vaccine, gene, drug and other biomolecules in the body. AIM OF WORK The present study aimed to develop stable Gel.NPs conjugated with nonstructural protein 2 (NS2) gen...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 107 شماره
صفحات -
تاریخ انتشار 1958